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mitotane will lower the level or impact of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of abemaciclib with solid CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.Abemaciclib targets CDK4 and CDK6, proteins that aid regulate cell division. Cancer